U.S. Clinical Trials Involving Headaches and Migraine Disease
Clinical trials are essential to the discovery of new medications, devices, and procedures to treat headaches and Migraine disease. Participation in clinical trials helps advance research and gives patients the opportunity to try treatments before they're available through their doctors. Here are listings for current clinical trials that are open for enrollment.
>>Be sure to scroll down the page to view all the links!<<
>>Be sure to scroll down the page to view all the links!<<
Clinical Trial NCT00330850: Migraine, PRO-513, Multi-State
An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack.
An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack.
Clinical Trial NCT00286923: Migraine, Chronic HA, Topamax, WA
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
Clinical Trial NCT00195741: Migraine, Depakote ER, IL
This Phase III, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Multi-Center Study Designed to Evaluate the Safety and Efficacy of Prophylactic Depakote ER in the Treatment of Adolescent Migraine.
This Phase III, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Multi-Center Study Designed to Evaluate the Safety and Efficacy of Prophylactic Depakote ER in the Treatment of Adolescent Migraine.
Clinical Trial NCT00283738: Migraine w/aura & PFO, STARFlex, Multi-St
Evaluate Safety/Effectiveness of PFO Closure With the STARFlex System to Resolve Refractory Migraine w/ Aura..
Evaluate Safety/Effectiveness of PFO Closure With the STARFlex System to Resolve Refractory Migraine w/ Aura..
Clinical Trial NCT00329355: Menstr. Migraine, Trexima, Multi-State
Menstrual Migraine Treatment With Trexima.
Menstrual Migraine Treatment With Trexima.
Clinical Trial NCT00329459: Menstr. Migraine, Trexima, Multi-State
Trexima Versus Placebo For Menstrual Migraine.
Trexima Versus Placebo For Menstrual Migraine.
Clinical Trial NCT00122278: Migraine, dexamethasone, NY
Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines.
Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines.
Clinical Trial NCT00123201: Migraine, Dronabinol MDI, Multi-State
Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache.
Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache.
Clinical Trial NCT00111722: Menstr Migraine, MK0462, Maxalt, Multi-State
Study to Test a Marketed Drug in the Treatment of Menstrual Migraine.
Study to Test a Marketed Drug in the Treatment of Menstrual Migraine.
Clinical Trial NCT00111709: Menstr. Migraine, MK0462, Maxalt, Multi-State
Study to Test a Marketed Drug in the Treatment of Menstrual Migraine.
Study to Test a Marketed Drug in the Treatment of Menstrual Migraine.
Clinical Trial NCT00259636: Migraine, Zonegran, PA
Zonisamide for Fibromyalgia & Migraine.
Zonisamide for Fibromyalgia & Migraine.
Clinical Trial NCT00250458: Migraine, MK0462, Maxalt, Multi-State
Study to Test a Marketed Product in the Treatment of Migraine-Associated Nausea.
Study to Test a Marketed Product in the Treatment of Migraine-Associated Nausea.
Clinical Trial NCT00158002: BTM, FHM, SHM, Topamax, VA
A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine.
A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine.
Clinical Trial NCT00208065: Migraine, Axert/Pseudoeph., MO
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers.
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers.
Clinical Trial NCT00195806: Migraine, Depakote ER, IL
Study Designed to Evaluate the Safety of Prophylactic Depakote ER in the Treatment of Adolescents With Migraine.
Study Designed to Evaluate the Safety of Prophylactic Depakote ER in the Treatment of Adolescents With Migraine.
Clinical Trial NCT00168428: Freq. Migraine, Botox, MO
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches.
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches.
Clinical Trial NCT00156910: Freq. Migraine, Botox, WA
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches.
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches.
Clinical Trial NCT00259649: Menstr. Migraine, Relpax, PA
Prospective Survey of Menstrual Migraine & Prevention With Eletriptan.
Prospective Survey of Menstrual Migraine & Prevention With Eletriptan.
Clinical Trial NCT00286078: Migraine, Neurostim, Multi-State
Treatment for Migraines With an Implantable Device .
Treatment for Migraines With an Implantable Device .
Clinical Trial NCT00203346: Migraine, Occ. Nerve Block, PA
Research Study Examining Nerve Block for Migraine.
Research Study Examining Nerve Block for Migraine.
Clinical Trial NCT00329771: Migraine, Allodynia Observation, PA
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.
Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.
Clinical Trial NCT00210496: Migraine, Topamax/Axert, Multi-State
Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine.
Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine.
Clinical Trial NCT00203307: Migraine, Zyprexa, PA
The Jefferson Headache Center at Thomas Jefferson University has developed this clinical study to evaluate the safety and effectiveness of Olanzapine in preventing migraine headaches.
The Jefferson Headache Center at Thomas Jefferson University has developed this clinical study to evaluate the safety and effectiveness of Olanzapine in preventing migraine headaches.
Clinical Trial NCT00329732: Migraine, bipivicaine/lidocaine, PA
Greater Occipital Nerve Blocks (GONB) are a common procedure used for the treatment of headache. Pocedure involves a series of injections into the greater occipital nerve (a spinal nerve located at the back of your head). The purpose of this study is to determine whether GONB is effective for the treatment of prolonged migraine attacks.
Greater Occipital Nerve Blocks (GONB) are a common procedure used for the treatment of headache. Pocedure involves a series of injections into the greater occipital nerve (a spinal nerve located at the back of your head). The purpose of this study is to determine whether GONB is effective for the treatment of prolonged migraine attacks.
Clinical Trial NCT00210535: Vascular HA/Migraine, Topamax, Multi-State
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the prevention of migraine attacks in children (12 to 17 years of age).
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the prevention of migraine attacks in children (12 to 17 years of age).
Clinical Trial NCT00298805: Migraine, Observation, NY
The purpose of this study is to compare depressive characteristics in migraine patients to those observed in patients with epilepsy in a previous study, and determine whether those symptoms are unique to patients with epilepsy.
The purpose of this study is to compare depressive characteristics in migraine patients to those observed in patients with epilepsy in a previous study, and determine whether those symptoms are unique to patients with epilepsy.
Clinical Trial NCT00335777: Migraine, Migranal, PA
This is a research study looking at Migranal in the treatment of two migraine attacks in patients who have a history of cutaneous allodynia, an increased skin sensitivity experienced during a headache.
This is a research study looking at Migranal in the treatment of two migraine attacks in patients who have a history of cutaneous allodynia, an increased skin sensitivity experienced during a headache.
Clinical Trial NCT00200109: Chronic Mig., ONS, U.S., Multi-State
The purpose of this study is to provide information to be used in developing a pivotal study for future FDA market approval.
The purpose of this study is to provide information to be used in developing a pivotal study for future FDA market approval.
Clinical Trial NCT00300924: Migraine, Maxalt/Acetamin, Multiple States
The purpose of this study is to test an experimental drug combination of two medications currently approved by the Food and Drug Administration (FDA) for migraine headache or other pain. These are called rizatriptan given with acetaminophen.
The purpose of this study is to test an experimental drug combination of two medications currently approved by the Food and Drug Administration (FDA) for migraine headache or other pain. These are called rizatriptan given with acetaminophen.
Clinical Trial NCT00287781: Migraine, Lidocaine, U.S., CA
Migraine headaches have previously been shown to be responsive to intranasal lidocaine in a small study. Using a nebulizer to administer the drug would improve the feasibility of using the treatment. It would also spare the patient narcotics with their attendant side effects. Because of the potential for placebo effect a placebo control is necessary in this study.
Migraine headaches have previously been shown to be responsive to intranasal lidocaine in a small study. Using a nebulizer to administer the drug would improve the feasibility of using the treatment. It would also spare the patient narcotics with their attendant side effects. Because of the potential for placebo effect a placebo control is necessary in this study.
Clinical Trial NCT00257010: Migraine, Axert, U.S., Multiple State
Axert. The purpose of this study is to evaluate the long-term safety of almotriptan malate (a migraine abortive medication) in the treatment of migraine headaches in adolescents for up to one year.
Axert. The purpose of this study is to evaluate the long-term safety of almotriptan malate (a migraine abortive medication) in the treatment of migraine headaches in adolescents for up to one year.
Clinical Trial NCT00267371: Migraine, PFO Closure U.S., Multi-State
ESCAPE Migraine Trial. The purpose of this study is to determine the safety and effectiveness of PFO closure (closing a hole in the wall of the heart) in reducing the frequency of migraine headaches, in patients who experience migraine headaches and have a PFO, compared to medical therapy alone.
ESCAPE Migraine Trial. The purpose of this study is to determine the safety and effectiveness of PFO closure (closing a hole in the wall of the heart) in reducing the frequency of migraine headaches, in patients who experience migraine headaches and have a PFO, compared to medical therapy alone.
Clinical Trial NCT00212810: Migraine, Topamax, U.S., Multi-State
Topamax. The purpose of this study is to determine whether Topiramate is effective in preventing the development of chronic daily headache among patients with episodic migraine headaches.
Topamax. The purpose of this study is to determine whether Topiramate is effective in preventing the development of chronic daily headache among patients with episodic migraine headaches.