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Midrin (isometheptene, dichloralphenazone, acetaminophen) Full Profile


Updated: May 24, 2006


Midrin® (acetaminophen, dichloralphenazone, and isometheptene)

Midrin is used to treat Migraine attacks and tension headaches. It should be taken only after headache pain begins, or after a warning sign that a Migraine is coming appears. Isometheptene helps to relieve throbbing headaches, but it is not an ordinary pain reliever. Dichloralphenazone helps you to relax, and acetaminophen relieves pain.

Type of medication: Rx, for acute relief of Migraine attacks and tension headaches

How supplied: Capsules, only one dosage.


  • Do not use more than two or three days a week as it can cause medication overuse headache, aka rebound.
  • Check with your doctor if:
    • The medication stops working as well as it used to.
    • If you have headaches or Migraines more frequently while using this medication.
  • Frequently causes drowsiness. Do not drive or operate machinery while taking this medication.
  • Be sure to check the labels of any prescription and OTC meds you may be taking to be sure not to combine Midrin with other medications that contain acetaminophen.

Pregnancy and Breastfeeding:

  • FDA pregnancy category C. This means that it is not known whether this drug will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
  • It is not known whether this medication passes into breast milk. Do not take without talking to your doctor if you are breast-feeding a baby.

Other medical conditions:
Make sure you tell your doctor if you have any other medical problems, especially those listed below.

  • alcohol abuse
  • stroke
  • kidney disease
  • glaucoma
  • heart or liver disease
  • uncontrolled blood pressure
  • poor circulation

Other medications:
Be sure to tell your doctor if you are taking any other prescription or over-the-counter medications, especially:

  • Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])-Taking this combination medicine while you are taking or within 2 weeks of taking a monoamine oxidase (MAO) inhibitor may increase the chance of side effects

Potential side effects:

Check with your doctor right away if any of the following side effects  occur:

  • Less common
    • Unusual tiredness or weakness
  • Rare
    • Black, tarry stools
    • blood in urine or stools
    • pinpoint red spots on skin
    • skin rash, hives, or itching
    • sore throat and fever
    • unusual bleeding or bruising
    • yellow eyes or skin
  • Symptoms of dependence on this medication:
    • Headaches, more severe and/or more frequent than before

Other side effects may occur that usually do not need medical attention. They may stop as your body adjusts to the medication. However, check with your doctor if any of the following side effects continue or are bothersome:

  • More common:
    • Drowsiness
  • Rare:
    • Dizziness
    • fast or irregular heartbeat

Brand Names:

  • U.S.:
    • Amidrine
    • Duradrin
    • I.D.A
    • Iso-Acetazone
    • Isocom
    • Midchlor
    • Midrin
    • Migrapap
    • Migquin
    • Migratine
    • Migrazone
    • Migrend
    • Migrex
    • Mitride
  • Canada: Not available

  1. About.com
  2. Health
  3. Headaches & Migraines
  4. Headache & Migraine Meds
  5. Medication Profiles
  6. Midrin (isometheptene, dichloralphenazone, acetaminophen) Full Profile. from About Headaches and Migraine

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