Other medications:
Always tell your doctor all medications you are taking, both prescription and over-the-counter. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking phenothiazines, it is especially important that your health care professional know if you are taking any of the following::
- Amantadine (e.g., Symmetrel)
- Antihypertensives (high blood pressure medicine)
- Bromocriptine (e.g., Parlodel)
- Deferoxamine (e.g., Desferal)
- Diuretics (water pills)
- Levobunolol (e.g., Betagan)
- Medicine for heart disease
- Metipranolol (e.g., OptiPranolol)
- Nabilone (e.g., Cesamet) (with high doses)
- Narcotic pain medicine
- Pentamidine (e.g., Pentam)-Severe low blood pressure may occur
- Antidepressants (medicine for depression)-The risk of developing serious side effects, including severe constipation, low blood pressure, severe drowsiness, unusual body or facial movements, and changes in heart rhythm, may be increased
- Antipsychotics, other (medicine for mental illness)
- Promethazine (e.g., Phenergan)
- Trimeprazine (e.g., Temaril)-Severe low blood pressure or unusual body or facial movements may occur
- Antithyroid agents (medicine for overactive thyroid)-The risk of developing serious blood problems may be increased
- Astemizole (e.g., Hismanal)
- Cisapride (e.g., Propulsid)
- Disopyramide (e.g., Norpace)
- Erythromycin (e.g., E.E.S., EryPed)
- Probucol (e.g., Lorelco)
- Procainamide (e.g., Procan SR)
- Quinidine (e.g., Duraquin)-Serious changes in heart rhythm may occur
- Central nervous system (CNS) depressants (medicines that cause drowsiness)-Severe drowsiness and trouble in breathing may occur
- Epinephrine (e.g., Adrenalin)-Severe low blood pressure and fast heartbeat may occur
- Levodopa (e.g., Dopar)-Phenothiazines may prevent levodopa from working properly in the treatment of Parkinson's disease
- Lithium (e.g., Lithane, Lithizine, Lithobid)-Some unwanted effects, such as decreased or unusual body or facial movements, may be increased. The blood levels of the phenothiazine and/or lithium may be changed, so the medicines may not work properly. Your doctor may need to change your dose of either or both medicines
- Metoclopramide (e.g., Reglan)
- Metyrosine (e.g., Demser)
- Pemoline (e.g., Cylert)
- Rauwolfia alkaloids (deserpidine [e.g., Harmonyl], rauwolfia serpentina [e.g., Raudixin], reserpine [e.g., Serpasil])-Taking these medicines with phenothiazines may increase the chance of having decreased or unusual body or facial movements or may make the movement problems worse
- Pimozide (e.g., Orap)-Serious changes in heart rhythm, severe low blood pressure, or unusual body or facial movements may occur.
