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Compazine: Headache and Migraine Drug Profiles.

CompazineŽ (Prochlorperazine)


Updated: June 16, 2006


Type of medication: Rx, antiemetic, phenothiazine
Prochlorperazineis often used to treat the nausea and vomiting and, to some extent, the pain associated with a Migraine attack. It also allows us to rest more easily and allows other medications to workbetter.

General information about Prochlorperazine:
Some Phenothiazines are used to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Prochlorperazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.


  • Oral
    • Extended-release capsules (U.S.)
    • Oral solution (U.S. and Canada)
    • Syrup (U.S. and Canada)
    • Tablets (U.S. and Canada)
  • Parenteral
    • Injection (U.S. and Canada)
  • Rectal
    • Suppositories (U.S.)


  • Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpromazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
  • Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
  • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking chlorpromazine.
  • Avoid prolonged exposure to sunlight. Chlorpromazine may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.

Pregnancy and Breastfeeding:

  • It is not known whether prochlorperazine will harm an unborn baby. Do not take chlorpromazine without first talking to your doctor if you are pregnant.
  • Prochlorperazine passes into breast milk and may affect a nursing baby. Do not take chlorpromazine without first talking to your doctor if you are breast-feeding a baby.

Other medical conditions:
Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse-Certain unwanted effects, such as heatstroke and liver disease, may be more likely tooccur
  • Blood disease
  • Breast cancer
  • Difficult urination
  • Glaucoma
  • Heart or blood vessel disease
  • Parkinson's disease
  • Seizure disorders, or history of
  • Stomach ulcers-Phenothiazines may make the condition worse
  • Brain damage
  • Blood vessel disease in the brain-Serious increase in body temperature may occur
  • Enlarged prostate-Difficulty in urinating may occur or may become more severe
  • Liver disease-Phenothiazines may make the condition worse. Higher blood levels of phenothiazines may occur, increasing the chance of having unwanted effects
  • Lung disease-Difficulty in breathing may become more severe. Decrease in cough reflex caused by phenothiazines may increase the risk of developing complications, such as pneumonia
  • Pheochromocytoma
  • Kidney disease-Severe low blood pressure may occur
  • Reye's syndrome-The risk that the phenothiazine will have unwanted effects on the liver may be increased
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  3. Headaches & Migraines
  4. Headache & Migraine Meds
  5. Medication Profiles
  6. Compazine® (Prochlorperazine): Headache and Migraine Drug Profiles.

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