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Celebrex: Headache and Migraine Drug Profiles.

Celebrex® (celecoxib)

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Created: May 23, 2004

Celebrex
Type of medication: Rx, Cox-Enzyme Inhibitor, NSAID, Migraine Preventive.
Celecoxib is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Celecoxib works by reducing substances that cause inflammation, pain, and fever in the body. Celecoxib is used to reduce pain, inflammation, and stiffness caused by osteoarthritis and rheumatoid arthritis. Celecoxib is also used to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), to treat acute pain, and to treat pain associated with menstruation. It is also sometimes prescribed as a Migraine preventive.

Precautions:

  • Do not take celecoxib without first talking to your doctor if you have
    • had an allergic reaction to a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Gantanol, and others), sulfisoxazole (Gantrisin), and others
    • experienced asthma, hives, or an allergic reaction after taking aspirin or another NSAID such as ibuprofen (Motrin, Advil, Nuprin, and others), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen (Orudis KT, Orudis, Oruvail), diclofenac (Voltaren, Cataflam), diflunisal (Dolobid), etodolac (Lodine, Lodine XL), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin).

Pregnancy and Breastfeeding:

  • FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Celecoxib should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart. Do not take celecoxib without first talking to your doctor if you are pregnant.
  • It is not known whether celecoxib passes into breast milk. Do not take celecoxib without first talking to your doctor if you are breast-feeding.

Other medical conditions:
Before taking this medication, be sure to tell your doctor if you:

  • smoke
  • drink alcohol
  • have an ulcer or bleeding in the stomach
  • have liver disease
  • have kidney disease
  • have asthma
  • have congestive heart failure
  • have fluid retention
  • have heart disease
  • have high blood pressure
  • have a coagulation (bleeding) disorder or are taking an anticoagulant (blood thinner) such as warfarin (Coumadin)
  • are taking a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others.

Other medications:
Before taking celecoxib, tell your doctor if you are taking any of the following drugs:

  • aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, Bayer Select Backache Formula, others)
  • an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, naproxen, or ketoprofen
  • a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), and others
  • an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and others
  • a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others
  • an anticoagulant (blood thinner) such as warfarin (Coumadin)
  • lithium (Eskalith, Lithobid, others)
  • fluconazole (Diflucan)

Potential side effects:

  • Dicsontinue celecoxib and contact your doctor immediately if you experience:
    • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives)
    • abdominal pain, tenderness, or discomfort
    • bloody, black, or tarry stools
    • nausea or heartburn
    • bloody vomit
    • unexplained weight gain
    • swelling or water retention
    • unusual fatigue or lethargy
    • a skin rash or itching
    • yellowing of your skin or eyes
    • "flu-like" symptoms
    • unusual bruising or bleeding
  • Other, less serious side effects may be more likely to occur. Continue to take celecoxib and talk to your doctor if you experience:
    • flatulence or diarrhea
    • dizziness
    • headache
    • insomnia

Brand Names:

  • U.S. & Canada: Celebrex

Additional Information:

Material on this page is for informational purposes only, and should not be construed as medical advice. Always consult your physician or pharmacist regarding medications.

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