1. Health
You can opt-out at any time. Please refer to our privacy policy for contact information.

Acetaminophen and Hydrocodone: Headache and Migraine Drug Profiles.

Acetaminophen and Hydrocodone: Lorcet, Lortab, Vicodin...


Updated: September 5, 2006

  • Do not take acetaminophen and hydrocodone if you have taken an MAOI)such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.
  • The most serious interactions affecting acetaminophen and hydrocodone are with those drugs that also cause sedation. Dangerous sedation may occur if acetaminophen and hydrocodone is taken with antihistamines; antidepressants; anticholinergics such as belladonna (Donnatal), clidinium (Quarzan), dicyclomine (Bentyl, Antispas), hyoscyamine (Levsin, Anaspaz), ipratropium (Atrovent), propantheline (Pro-Banthine), and scopolamine (Transderm-Scop), phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), thioridazine (Mellaril), and prochlorperazine (Compazine), and tranquilizers and sedatives. Do not take any of these drugs with acetaminophen/hydrocodone without your doctor's approval.
  • do not take any of the following medicines together with acetaminophen for more than a few days, unless under doctor's supervision: Aspirin, Diclofenac (Voltaren), Diflunisal (Dolobid), Etodolac (Lodine), Fenoprofen (Nalfon), Floctafenine (Idarac), Flurbiprofen (Ansaid), Ibuprofen (Advil, Motrin), Indomethacin (Indocin), Ketoprofen (Orudis), Ketorolac (Toradol), Meclofenamate (Meclomen), Nabumetone (Relafen), Naproxen (Naprosyn), Oxaprozin (Daypro), Piroxicam (Feldene) 
  • The drugs listed above may reduce the effects of acetaminophen and/or increase the risk of damage to your liver. You may require a lower dose or special monitoring during treatment if you are taking any of the medicines listed above.
  • Avoid alcohol. Alcohol taken during therapy with acetaminophen can be very damaging to your liver.
  • Be aware of the acetaminophen content of other over-the-counter and prescription drugs.
  • Acetaminophen may cause false urine glucose test results. Talk to your doctor if you are diabetic and you notice changes in your glucose levels while you are taking acetaminophen.

Potential side effects:

  • Stop taking acetaminophen and hydrocodone and seek emergency medical attention if you experience any of the following:
    • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives)
    • slow, weak breathing
    • seizures
    • cold, clammy skin
    • severe weakness or dizziness
    • unconsciousness
    • yellowing of the skin or eyes
    • unusual fatigue, bleeding, or bruising
  • Continue to take acetaminophen and hydrocodone and talk to your doctor if you experience any of these less serious side effects:
    • constipation
    • dry mouth, nausea, vomiting, or decreased appetite
    • dizziness, tiredness, or lightheadedness
    • muscle twitches
    • sweating
    • itching
    • decreased urination
    • decreased sex drive

Brand Names:


  • Allay
  • Anexsia
  • Anolor DH
  • Bancap-HC
  • Co-Gesic
  • Dolacet
  • Dolagesic
  • Duocet
  • Hycomed
  • Hydrocet
  • Hydrogesic
  • Lorcet
  • Lortab
  • Margesic-H
  • Norco
  • Oncet
  • Panacet
  • Panlor
  • Polygesic
  • Stagesic
  • T-Gesic
  • Ugesic
  • Vanacet
  • Vendone
  • Vicodin
  • Vicodin ES
  • Zydone
  • others

More information:

  • Medication Overuse Headache: What's a person to do?
    Unfortunately, it seems that any medication we take for headache or Migraine relief has the potential to cause medication overuse headache if used more than two or three days a week. We need to learn as much about it as possible. Let’s take a look at what causes it, how to avoid it, and other important issues.

Material on this page is for informational purposes only, and should not be construed as medical advice. Always consult your physician or pharmacist regarding medications.

  1. About.com
  2. Health
  3. Headaches & Migraines

©2014 About.com. All rights reserved.

We comply with the HONcode standard
for trustworthy health
information: verify here.