Brain & Nervous System Headaches Causes & Risk Factors Connection Between Headaches and Hormones By Colleen Doherty, MD Updated on June 25, 2022 Medically reviewed by Diana Apetauerova, MD Print For some people, their headaches are linked to their hormones, meaning underlying health conditions that impact hormones in their body are the source or trigger for their headaches. Hero Images / Getty Images Thyroid Hormone and Headaches People who have a low level of thyroid hormone are considered hypothyroid. Since the thyroid gland is involved in a number of metabolic processes in the body, symptoms of hypothyroidism are variable in number and severity but may include weight gain, fatigue, dry skin, and constipation. In addition, people with hypothyroidism may also experience headaches that are related to their thyroid state. This headache is similar to a tension headache in that it feels like a band around the head and is generally not throbbing, like a migraine. By definition, a headache attributed to hypothyroidism is one in which symptoms resolve within two months after the thyroid levels are normalized. Estrogen and Headaches Many endure migraines triggered by a drop in estrogen just before they begin menstruating. This is called a menstrual migraine. Symptoms of a menstrual migraine resemble a non-menstrual migraine but are often more intense and more resistant to treatment. For someone who gets menstrual migraines frequently, a healthcare provider may recommend taking a long-acting triptan starting a couple of days prior to menstruation for a total of five to six days. This can help prevent a migraine attack from occurring in the first place. Combined estrogen-progesterone birth control pills, especially continuous pills, may also help prevent menstrual migraines in certain individuals who menstruate. Stress Hormone and Headaches Stress is a major headache trigger and can cause a person to develop a new headache disorder or worsen an already existent headache disorder. Stress can also trigger the evolution of episodic headaches to chronic headaches. While the exact ways in which stress affects a person's headache health is unclear, it's likely that the stress hormone cortisol plays a role. Cortisol is a hormone released by the adrenal glands (small glands that sit upon your two kidneys) when a person experiences stress. Cortisol has a number of effects on the body, such as increasing the heart rate and raising a person's blood sugar. It may also trigger headaches through a complex interaction with a person's nervous system. Glucose, Insulin, and Headaches A drop in glucose levels, which can occur from not eating or taking too much insulin, can trigger a hypoglycemia-induced migraine. In addition, some people develop a headache when they stop eating, even if their glucose levels do not drop too low, and this is called a fasting headache. Interestingly, scientists do not think that a fasting headache is really from low glucose levels, but rather from some other process, like the stress in the body induced by fasting. A fasting headache is generalized, meaning it's felt all over the head, and it's also typically non-throbbing, like a tension headache. The treatment for a fasting headache is eating, but it may still take up to 72 hours to resolve after consuming a meal. There also appears to be a link between chronic migraines and insulin resistance, especially in overweight individuals. Insulin resistance means that a person produces insulin, but it's not used appropriately to lower blood sugar levels, and it predisposes a person to the development of type 2 diabetes mellitus. The link between migraines and insulin resistance is unclear. It may be that people with insulin resistance tend to be overweight, which increases inflammation in the body. This inflammation could then make a person more prone to migraine attacks—and research has found that overweight people assigned female at birth do have more frequent migraine attacks than those of "normal" weight (but not necessarily longer or more severe migraines). A Word From Verywell If you think your headaches are linked to your hormones, speak with a healthcare provider. A good medical history and a few simple blood tests will help identify the cause and suggest appropriate treatment. 11 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23;390(10101):1550-62. doi:10.1016/S0140-6736(17)30703-1 Lisotto C, Mainardi F, Maggioni F, Zanchin G. The comorbidity between migraine and hypothyroidism. J Headache Pain. 2013;14(Suppl 1):P138. doi:10.1186/1129-2377-14-S1-P138 Petrovski BE, Vetvik KG, Lundqvist C, Eberhard-Gran M. Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study. J Headache Pain. 2018;19(1):27. doi:10.1186/s10194-018-0853-3 Hu Y, Guan X, Fan L, Jin L. Triptans in prevention of menstrual migraine: a systematic review with meta-analysis. J Headache Pain. 2013;14(1):7. doi:10.1186/1129-2377-14-7 De Leo V, Scolaro V, Musacchio MC, et al. Combined oral contraceptives in women with menstrual migraine without aura. Fertil Steril. 2011 Oct 1;96(4):917-20. doi:10.1016/j.fertnstert.2011.07.1089 Murphy C, Hameed S. Chronic headaches. In: StatPearls [Internet]. Lippi G, Mattiuzzi C. Cortisol and migraine: a systematic literature review. Agri. 2017 Jul;29(3):95-9. doi:10.5505/agri.2017.25348. Fagherazzi G, El Fatouhi D, Fournier A, et al. Associations between migraine and type 2 diabetes in women. JAMA Neurol. 2019 Mar;76(3):257-63. doi:10.1001/jamaneurol.2018.3960 Dalkara T, Kiliç K. How does fasting trigger migraine? A hypothesis. Curr Pain Headache Rep. 2013 Oct;17(10):368. doi:10.1007/s11916-013-0368-1 El-Mitwalli, A. Ramadan fasting and neurologic disorders. In: Neurology and Religion. Cambridge MA, Cambridge University Press, 2019. doi:10.1017/9781316014165.013 Verrotti A, Di Fonzo A, Penta L, Agostinelli S, Parisi P. Obesity and headache/migraine: the importance of weight reduction through lifestyle modifications. Biomed Res Int. 2014;2014:420858. doi:10.1155/2014/420858 Additional Reading Berry JKM, Drummond PD. Psychological generators of stress-headaches. J Behav Med. 2018 Feb;41(1):109-21. doi:10.1007/s10865-017-9872-9 Fava A, Pirratano D, Consoli D, et al. Chronic migraine in women is associated with insulin resistance: a cross-sectional study. Eur J Neurol. 2014 Feb;21(2):267-72. doi:10.1111/ene.12289 Huang Q, Liang X, Wang S, Mu X. Association between body mass index and migraine: a Survey of adult population in China. Behav Neurol. 2018 Apr 19;2018:6585734. doi:10.1155/2018/6585734 By Colleen Doherty, MD Dr. Doherty is a board-certified internist and writer living with multiple sclerosis. She is based in Chicago. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit