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Topamax, Zonegran for hemiplegic Migraine prevention? Others?

From John Claude Krusz, MD, PhD, and Teri Robert, for About.com

Created: July 10, 2006

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

Question: Topamax, Zonegran for hemiplegic Migraine prevention? Others?

Answer:

Full Question:

I've suffered from Hemiplegic migraines for over 12 years. I am currently taking Sandomigran to prevent attacks, having been experiencing 3-4 per month recently. I have experienced weight gain, drowsiness and fluid retention on Sandomigran and have read conflicting information regarding it's use for treatment of hemiplegic. My doctor is now considering Topamax or Zonegran for treatment. Are either of these two suitable for hemiplegic? What other medications may be suitable? Many thanks, Renee.
 

Answer:

Dear Renee;

Sandomigran is no longer even available in the U.S. One reason it fell out of favor for prevention is that you have to take a "vacation" from it about every six months, and nobody wants to face a possible increase in Migraines because of having to periodically stop their preventive.

Both Topamax and Zonegran have been working quite well for many patients. Another medication that has been shown to be effective in prevention of hemiplegic Migraine is the calcium channel blocker verapamil, especially in its time-release formulas. There are a great many medications that would be potentially helpful for prevention. You can find a list here:

    Medications for Headache and Migraine Prevention
    For those of us with frequent headaches or Migraine attacks, preventive medications, dietary supplements, and even medical devices are often a good option. There are over 100 medications that can be used and nearly endless combinations of them. The list is ever-evolving, and will this one will be updated regularly.

Good luck,
Teri Robert and John Claude Krusz

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