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Abilify for Migraine prevention?

From John Claude Krusz, MD, PhD, and Teri Robert, for About.com

Created: July 10, 2006

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

Question: Abilify for Migraine prevention?

Answer:

Full Question:

I have been battling daily chronic migraines for 30 years now. My question is: Has there been any medical knowledge whether Abilify has been useful for daily chronic migraines? A girl I met at MHNI (Michigan Head*Pain and Neurological Institute) when I was there for the month of August 2004 under Dr. Saper/Rozen's care has finally found relief from her daily migraines with Abilify, 1/4 pill, so she has leeway in titrating the dosage if need be. I have been using Suboxone 2mg. which was helpful in reducing my head pain at first to a level '3', but now I've acclimated to the Suboxone, and of course, it's not helping the daily pain. I use Relpax OR DHE injections, my doctors and I have decided to treat the pain, and not go with preventives any longer, as ALL the preventives we've used in 30 years have not penetrated the head pain. I was told by Saper/Rozen that I 'had a sentence of a lifetime of pain', and that I was a failure (I appropriately disagreed). Any thoughts on Abilify would be appreciated. Please know after 30 years, I HAVE tried the preventives, and also used medications that were not specifically FOR treating migraines (Namenda). Thank you for your time, I see you have been a great help for others, and also Teri has too. Julie.
 

Answer:

Dear Julie;

Obviously you have consulted with some very well-known names in the headache field. I have some positive data on Abilify (and the other 4 members of that family) on reducing chronic and even daily headaches and Migraines. So, it might be a reasonable choice. Don't give up; it only gets better and easier to treat tough headaches as newer meds hit the market. You need to be careful, especially with DHE as it's pretty well know to cause rebound headaches when used more than a couple of days a week.

We've accumulated a list of over 100 medications and supplements for prevention. I'm sure you've tried more than your share of preventives, but it's possible that there's something there that you haven't heard of yet. If you'd like to take a look at the list for things you haven't tried, you can find it at:

    Medications for Headache and Migraine Prevention
    For those of us with frequent headaches or Migraine attacks, preventive medications, dietary supplements, and even medical devices are often a good option. There are over 100 medications that can be used and nearly endless combinations of them. The list is ever-evolving, and will this one will be updated regularly.

Thanks for your kind comment. It's nice to know that the column is helpful to you.

Good luck,
Teri Robert and John Claude Krusz

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Important Note: Material on this page is for informational purposes only, and should not in any way be construed as medical advice. Always consult your own physician with questions about your headaches or Migraines.

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