Question: How do antidepressants help prevent Migraines?
Answer:
Full Question:
I’ve read several different articles stating
that anti-depressants can be used to prevent Migraines, but none of them talk
about how they work to in prophylaxis. Can you explain? Thank you, Marijane.
Answer:
Dear Marijane;
Depends on what type of headache. There is very little positive data on tricyclic antidepressants (TCAs) and SSRIs having stunning effects on Migraines. There is no agent in either category that is officially approved for Migraine treatment in the US. Yet, many doctors use TCAs to suppress Migraines, and they do help in some cases. For treating chronic daily headaches, there is some data with these agents but, again, no agent is officially approved. The mechanism is not understood but it may have to do with their effects on serotonin in the brain.
Good luck,
Teri Robert and John Claude Krusz
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Published March 27, 2006
