Zomig^®, Zomig-ZMT^®
(zolmitriptan)

Zolmitriptan is an antimigraine medication, and should not be used to relieve any kind of pain other than Migraine.  Many people find that their Migraines go away completely after they take zolmitriptan. Other people find that their Migraines are much less painful, and that they are able to go back to their normal activities even though their Migraines are not completely gone. Zolmitriptan often relieves symptoms that occur together with Migraine pain, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

How supplied: 2.55 mg and 5 mg tablets, nasal spray, 2.5 mg orally dissolving tablets (U.S. only).

Precautions:
Zolmitriptan is generally not prescribed under these conditions:

• presence or risk factors for coronary artery disease
• angina, fast or irregular heartbeat
• history of heart attack
• uncontrolled hypertension
• basilar or hemiplegic Migraines
• history of stroke
• Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.
• allergy to or strong sensitivity to aspartame (orally dissolving tablets only)
• Do NOT take Imitrex within 24 hours of taking any other triptan unless specifically told to do so by your doctor.
• Do NOT take Imitrex within 24 hours of taking any ergotamine medication such as DHE or Migranal.

Pregnancy and Breastfeeding:

• FDA pregnancy category C. This means that it is not known whether this drug will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
• It is not known whether this medication passes into breast milk. Do not take without talking to your doctor if you are breast-feeding a baby.

Other medical conditions:
The presence of other medical problems may affect the use of zolmitriptan. Make sure you tell your doctor if you have any other medical problems, especially those listed below. Heart or blood vessel disease and high blood pressure sometimes do not cause any symptoms, so some people do not know that they have these problems. Before deciding whether you should use zolmitriptan, your doctor may need to do some tests to make sure that you do not have any of these conditions.

• angina, heart or blood vessel disease
• fast or irregular heart beat
• uncontrolled high blood pressure
• kidney disease
• liver disease
• stroke (history of)--The chance of side effects may be increased.
• Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.
• seizures or Epilepsy
• basilar or hemiplegic Migraine

Other medications:
Be sure to tell your doctor if you are taking any other prescription or over-the-counter medications, especially other prescription medicine for Migraine or depression.

• Do not take zolmitriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) within the last 14 days. The combination could cause seizures, nausea, vomiting, sweating, flushing, and dizziness.
• Do not take zolmitriptan if you have taken any of the following medicines within the previous 24 hours:
  • ergot-based medications such as methysergide (Sansert), ergotamine (Ergostat), dihydroergotamine (D.H.E., Migranal Nasal Spray), and ergotamine combination products (Cafergot, Ercaf, Wigraine, Cafatine, Cafatine-PB, Cafetrate).
  • another triptan such as zolmitriptan (Maxalt, Maxalt-MLT), naratriptan (Amerge), zolmitriptan (Zomig), almotriptan (Axert), frovatriptan (Frova), or eletriptan (Relpax)
• Before taking zolmitriptan, tell your doctor if you are taking
  • a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or citalopram (Celexa); or
  • propranolol (Inderal)

Potential side effects:

• Stop using zolmitriptan and contact your doctor immediately if any of the following side effects occur:
  • severe chest pain
  • heaviness, tightness, or pressure in chest and/or neck
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
  • changes in facial skin color
  • cough or hoarseness
  • difficulty in swallowing
  • increased or irregular heartbeat
  • fever or chills
  • rash, hives, itching, or bumps on skin
  • shortness of breath
  • lower back, side, or abdominal pain
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, or lips
  • shortness of breath, troubled breathing, tightness in chest, and/or wheezing
  • skin rash, hives, and/or itching
• Some of the following effects, such as nausea, vomiting, drowsiness, dizziness, and general feeling of illness or tiredness, often occur during or after a migraine, even when zolmitriptan has not been used. However, check with your doctor if any of the following side effects continue or are bothersome:
  • dizziness
  • nausea
  • sleepiness
  • unusual tiredness or muscle weakness
  • agitation, anxiety, or depression
  • discomfort in jaw, mouth, or throat
  • difficulty in swallowing
  • dry mouth
  • fainting
  • heartburn
  • itching of the skin
  • large nonelevated blue or purplish patches in the skin
  • muscle aches
  • sudden large increase in frequency and quantity of urine
  • sweating
  • swelling of face, fingers, feet and/or lower legs

Brand Names:

• U.S.: Zomig, Zomig-ZMT (orally dissolving tablets)
• Canada: Zomig
• U.K.: Zomig
• Australia: Not available

More Information:

• Zomig Now Approved In Nasal Spray Form
• FDA-approved prescribing info, Zomig®
• FDA-approved prescribing info, Zomig-ZMT®