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Headache  & Migraine Medications
(listed alphabetically)

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Neurontin (Gabapentin)
  • Rx, preventive, anticonvulsant
  • Brand Name in US and Canada: Neurontin; also commonly called GBP
  • Used as a migraine preventive
  • Other medications: Antacids can lower the blood level of Neurontin, so Neurontin should be taken at least two hours after antacids. Gabapentin may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants.
  • Be sure to tell your doctor if you have any other medical conditions, especially kidney, liver, or heart disease
  • FDA pregnancy category C. This means that it is not known whether gabapentin will harm an unborn baby. Do not take gabapentin without first talking to your doctor if you are pregnant.
  • t is not known whether gabapentin passes into breast milk. Do not take gabapentin without first talking to your doctor if you are breast-feeding a baby.
  • Possible side effects:
    • More common: clumsiness or unsteadiness; continuous, uncontrolled, back-and-forth and/or rolling eye movements
    • More common in patients 3 to 12 years of age: aggressive behaviors or other behavior problems; anxiety; concentration problems and change in school performance; crying; false sense of well-being; hyperactivity or increase in body movements; mental depression; reacting too quickly, too emotionally, or overreacting; rapidly changing moods; restlessness; suspiciousness or distrust
    • Less common: depression, irritability, or other mood or mental changes; loss of memory
    • Rare: cough or hoarseness; fever or chills; lower back or side pain; painful or difficult urination
  • FDA approved prescribing information

Naprosyn (Naproxen)
  • Rx, NSAID
  • tablets
  • used for mild to moderate migraine, tension, menstrual headache and intractable migraine
  • should be taken at first indication of headache
  • major potential for rebound headache, should generally not be used for more than three days consecutively
  • FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Naproxen should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take naproxen without first talking to your doctor if you are pregnant.
  • passes into breast milk and may harm a nursing infant. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.
  • Be sure to tell your doctor if you have an allergy to aspirin or any other NSAIDs, an ulcer or bleeding in your stomach, liver disease, kidney disease, a bleeding disorder, congestive heart failure, fluid retention, heart disease,  high blood pressure, or if you drink more than three alcoholic beverages a day.
  • Avoid prolonged exposure to sunlight. Naproxen may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.
  • Use caution when driving, operating machinery, or performing other hazardous activities. Naproxen may cause dizziness. If you experience dizziness, avoid these activities.
  • If you drink more than three alcoholic beverages a day, naproxen may increase the risk of stomach bleeding.
  • Be sure to tell your doctor of all medications you take, especiallyother nonsteroidal anti-inflammatory drugs (NSAIDs); aspirin and other salicylates; diuretics; anticoagulants; steroids such as prednisone; alcohol; oral antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase, Diabeta); lithium; cyclosporine; or bismuth subsalicylate in drugs such as Pepto-Bismol.
  • Naproxen can also decrease the effects of other drugs, such as ACE inhibitors and beta blockers.
  • Potential side effects:
    • Discontinue and contact your doctor immediately if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); muscle cramps, numbness, or tingling; mouth ulcers; rapid weight gain (fluid retention); seizures; black, bloody, or tarry stools; blood in your urine or vomit; decreased hearing or ringing in the ears; jaundice; or abdominal cramping, heartburn, or indigestion.

Nortriptyline 
  • Rx, tricyclic antidepressant, Migraine preventive
  • Brand names (U.S.): Aventyl, Pamelor
  • Brand names (Canada): Aventyl
  • It is not known whether nortriptyline will harm an unborn baby. Do not take nortriptyline without first talking to your doctor if you are pregnant.
  • The effects of nortriptyline on a nursing baby are unknown. Do not take nortriptyline without first talking to your doctor if you are breast-feeding a baby.
  • Be sure to tell your doctor if you have liver disease, kidney disease, asthma, thyroid disease, diabetes, stomach or intestinal problems, high blood pressure or heart disease, had a heart attack in the last 6 weeks, an enlarged prostate or difficulty urinating, or glaucoma.
  • Do not take nortriptyline if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the last 14 days.
  • Nortriptyline may increase the effects of other drugs that cause drowsiness, including other antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines without first talking to your doctor.
  • Drugs other than those listed here may also interact with nortriptyline. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
  • Potential side effects:
    • Discontinue and consult your doctor immediately if you experience an allergic reaction (swelling of the lips, face, or tongue; difficulty breathing); seizures; a fast or irregular heartbeat; heart attack; high blood pressure (blurred vision, severe headache); difficulty urinating; or fever with increased sweating, muscle stiffness, or severe muscle weakness.
    • Continue taking, but consult your doctor, if you experience mild drowsiness or dizziness; dry mouth and eyes; constipation; mild tremor; sweating; mild agitation, weakness, or headache; ringing in the ears; nausea; or loss of weight or appetite.

Nubain 
  • Rx, narcotic analgesic, opioid
  • nalbuphine 10 mg/ml, 20 mg/ml
  • injectable
  • possible side effects include: nausea, vomiting, constipation, depression of respiration
  • sedating
  • potentially addictive
  • strong potential for rebound headaches

Material on this page is for informational purposes only,
and should not be construed as medical advice.
Always consult your physician or pharmacist regarding medications.

 


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